DEEP MUTATIONAL SCANNING REVEALS TRANSMEMBRANE FEATURES GOVERNING SURFACE EXPRESSION OF THE B CELL ANTIGEN RECEPTOR

B cells surveil the body for foreign matter using their surface-expressed B cell antigen receptor (BCR), a tetrameric complex comprising a membrane-tethered antibody (mIg) that binds antigens and a signaling dimer (CD79AB) that conveys this interaction to the B cell.Recent cryogenic electron microscopy (cryo-EM) structures of IgM and IgG isotype BC

Abstract The pathogenesis of HIV infection, and in particular the development of immunodeficiency, remains incompletely Upright Wire understood.Whichever intricate molecular mechanisms are at play between HIV and the host, it is evident that the organism is incapable of restricting and eradicating the invading pathogen.Both innate and adaptive immu